Epidemiological studies have shown that the incidence of liver cancer and chronic liver disease has increased rapidly over the past 30 years, seriously endangering the health of people of all races in the United States. Studies have found that regular coffee consumption has a protective effect on the liver, and because of the great racial variability in the development of liver cancer, there is no literature that clearly reports that coffee reduces the incidence of liver cancer in ethnic minorities in the United States. A study conducted by scholars at the University of Southern California Norris Comprehensive Cancer Center found that coffee consumption similarly reduced the risk of liver cancer and chronic liver disease in ethnic minorities in the United States. The article was recently published in the journal Gastroenterology. The prospective cohort study included more than 215,000 volunteers from different ethnic groups in the U.S. Volunteers were asked to report their coffee intake in addition to other dietary and lifestyle-related factors. During 18 years of follow-up, 451 volunteers developed liver cancer and 654 died of chronic liver disease. Cox regression analysis was used to calculate the relative risk (RR) and 95% confidence interval (95% CI). The results of the study showed that coffee consumption significantly reduced the incidence of liver cancer and mortality from chronic liver disease (p < 0.0002). Compared to non-coffee drinkers, volunteers who drank 2-3 cups of coffee per day had a 38% reduction in the incidence of liver cancer and a 46% reduction in mortality from chronic liver disease, while those who drank more than 4 cups of coffee per day had a 41% reduction in the incidence of liver cancer and a 71% reduction in mortality from chronic liver disease. The study also found that coffee intake was inversely associated with liver cancer and chronic liver disease, but not significantly different from the volunteers' race, gender, body mass index, smoking, alcohol consumption and diabetes (p≥0.11). The mechanism of coffee on liver protection is not fully clarified, and it is speculated that it may be related to lowering liver enzymes (glutamate transaminase, glutamyl transaminase, and glutaryl transaminase) and delaying the progression of liver disease. Also, coffee may reduce insulin resistance and improve glucose metabolism to reduce the incidence of diabetes and indirectly reduce the incidence of liver disease. It has been reported that the main active components of coffee for liver protection are likely caffeine, diterpenes and chlorogenic acid. In conclusion, coffee can reduce the incidence of hepatocellular carcinoma and the mortality of chronic liver disease without variability among various ethnic groups, but the exact mechanism of its prevention of hepatocellular carcinoma and chronic liver disease and its active ingredients are not fully understood and need to be further studied. The above studies show that coffee can prevent the occurrence of liver cancer and chronic liver disease, and China is one of the countries with a high incidence of liver disease. Liver disease has brought a heavy burden to our national economy people's health, so the research results of the hepatoprotective effect of coffee in various ethnic populations in the United States are worthy of reference, study and in-depth research in our medical community.