Kidney essence deficiency generally refers to insufficient kidney essence. Which is more difficult to treat, kidney essence deficiency or kidney yin deficiency, is mainly affected by the severity of the condition, personal situation, treatment methods and other factors, and cannot be generalized and is not comparable. It can be treated mainly by traditional Chinese medicine. 1. Kidney essence deficiency: mainly manifested as retarded growth and development of children, infertility of men with low sperm count, infertility of women with menstrual closure, and hypogonadism. The available prescription drugs are Heche Dazao Pills, etc., and Chinese medicines include yam, atractylodes macrocephala, poria, ginseng, jujube kernel, Colla Corii Asini, and sequestrum. 2. Kidney Yin deficiency: manifested as dizziness, pale or grayish-black color, soreness and pain in the waist and knees, and coldness in the whole body. Prescription medicines available include Zuo Gui Wan and Liu Wei Di Huang Tang, etc. Chinese medicines include wolfberry, chrysanthemum, Zhi Mu, cypress, oyster, and Jin Zhen Zi. Which is more difficult to treat, kidney essence deficiency or kidney yin deficiency, is mainly affected by the severity of the condition, personal situation, treatment methods and other factors, there is no such thing as which is more difficult to treat. If medication is needed, it should be used under the guidance of a TCM doctor.