Radiotherapy for common gliomas

  Hairy cell astrocytoma This tumor is commonly found in children and adolescents, classified as grade I according to WHO, and is commonly found in midline sites such as the inferior optic thalamus, cerebellum, and hairy cell astrocytoma in the spinal cord, commonly in elderly patients. The tumor is largely confined, and a certain degree of brain parenchymal infiltration still exists microscopically, and total surgical excision is the best method for radical treatment. However, it is difficult to achieve pathologically complete resection of intra-spinal hairy cell astrocytoma. Patients who are not completely resected should be treated with local radiotherapy with conventional segmentation of 1.8~2.0Gy, DT54Gy, PTV for MRT2 image on the edema zone of 1.5~2cm can be released.  Subventricular giant cell type astrocytoma This tumor is mostly seen in young people and is part of the tuberous sclerosis misshapen lesions. I saw a case of a 23-year-old female patient with a subventricular giant cell astrocytoma (pathologically confirmed) in the right ventricular wall near the foramen ovale area, approximately 1.5 cm in diameter, with renal malrotation hemangioma and hepatic cavernous hemangioma. It is recognized by WHO as a limited astrocytoma, and no malignancy has been reported. Total surgical excision can be curative, but partial excision also requires radiotherapy, which is planned as above.  Protoplasmic astrocytoma and oligodendroglial cell tumor are diffuse infiltrative growth tumors, WHO grade II, and require postoperative radiotherapy with or without total excision.  Pleomorphic yellow astrocytoma and obese astrocytoma The former is a rare tumor, which is classified as grade II~III in WHO classification and has certain aggressiveness. The latter is a transitional astrocytoma, and its appearance indicates a tendency of malignant infiltration. Both types of radiotherapy should be treated as malignant glioma.  Malignant gliomas, including mesenchymal astrocytoma, glioblastoma, and mesenchymal oligodendroglioma, are all moderately to highly malignant gliomas that are resistant to radiation, and distant metastases are relatively common. The currently recommended treatment plan is: surgery + radiotherapy + chemotherapy, local radiotherapy range PTV should include 3-4cm of edema zone outwardly on MRT2 image, after irradiation of 50Gy, field reduction and replenishment to 60-64Gy can be considered. if the tumor is obviously residual after surgery, X-knife or 3DCRT replenishment can be considered, if the patient has difficulty in long-term survival, palliative radiotherapy of 3Gy×10f or 2.5Gy×20f can be used. It is generally believed that there is no significant difference in the effect of treatment with conventional segmentation, large segmentation or hyper-segmentation but there are many controversies. Whole-brain irradiation was once the usual treatment for malignant glioma, but most recent studies have shown that whole-brain radiotherapy is unnecessary in the absence of conclusive evidence of tumor implantation and metastasis.