Secondary hyperlipidemia is caused by other primary diseases, including diabetes, liver disease, thyroid disease, kidney disease, pancreas, obesity, glycogen accumulation disease, gout, Addison’s disease, Cushing’s syndrome, abnormal globulinemia, etc. Secondary hyperlipoproteinemia is quite common in clinical practice. Without detailed examination, the primary disease can often be overlooked, treating the symptoms but not the root cause of the problem, which is detrimental to treatment. The following is a brief description. Diabetes and hyperlipoproteinemia There is a close relationship between glucose metabolism and fat metabolism in the human body, and clinical studies have found that about 40% of diabetic patients can be secondary to hyperlipidemia. In general, patients with insulin-dependent diabetes mellitus have metabolic disorders of celiac disease (CM) and very low density lipoprotein (VLDL) in the blood most often, which is related to the severity of the disease. In patients with severe insulin deficiency, especially with ketoacidosis, both of these lipoproteins are significantly increased, manifesting as type I or V hyperlipoproteinemia. In lighter patients without ketosis, celiac particles may be absent from the blood and very low density lipoproteins may be normal or only mildly increased (type IV hyperlipoproteinemia). These metabolic abnormalities can be improved with insulin therapy. Abnormalities in lipoprotein metabolism are more common in non-insulin-dependent diabetes mellitus and may be related to the fact that this type of diabetes mellitus is most often combined with obesity. Clinical observations show that many patients with this type of diabetes mellitus do not have obvious symptoms and are only detected when they present with coronary heart disease, stroke or other peripheral vascular disease and hyperlipidemia and undergo further blood glucose examination. Therefore, it is believed that non-insulin-dependent diabetes, obesity, hyperlipidemia and coronary artery disease are the most common syndromes among middle-aged and elderly people. After weight control and restriction of sugar (e.g., carbohydrates, etc.) intake, lipoprotein abnormalities in such patients will be improved to some extent. 2, liver disease and hyperlipoproteinemia Modern medical research data confirm that many substances, including lipids and lipoproteins, are processed, produced, broken down and excreted in the liver. Once the liver is diseased, the lipid and lipoprotein metabolism will also be disrupted. Take the most common fatty liver in middle-aged and elderly people as an example, it can be seen in clinical observation that fatty liver, regardless of the cause, may cause an increase in lipid and very low density lipoprotein (VLDL) content, manifesting as type IV hyperlipoproteinemia. At a later stage, the further development of hepatocellular damage, plasma triglycerides and VLDL content can be reduced, and even appear hypolipoproteinemia. 3, obesity and hyperlipoproteinemia clinical medical research data show that obesity most often secondary to the increase in blood triglyceride content, some patients may also increase blood cholesterol content, mainly for the performance of type IV hyperlipoproteinemia, followed by type IIb hyperlipoproteinemia. Modern medical research results clearly suggest that hormonal (such as insulin; thyroxine, adrenocorticotropic hormone, etc.) changes caused by physiological and pathological (including those caused by drug abuse, etc.) changes and metabolic (especially glucose metabolism) abnormalities can cause hyperlipidemia. 4, gender factors Adult women have lower cholesterol levels than men before the age of 40; after the age of 50 at menopause, cholesterol gradually rises and can often exceed that of men, and the incidence of remembered myocardial infarction is 2-3 times higher than that of men. Women who take contraceptives for a long time can also make triglycerides rise, and increased plasma triglycerides are often an independent risk factor for cardiovascular disease in women over 50 years of age. The plasma HDL level gradually begins to decline after the start of menopause in women, and when the plasma HDL drops by 0.26 mmol/L, it can increase the risk of cardiovascular disease by 4.2%. 5.Drugs and hyperlipidemia Hyperlipidemia caused by long-term use of certain drugs, such as: contraceptives, hormonal drugs, diuretics, alpha-blockers, beta-blockers, antipsychotics, etc.