Recovery from massive cerebral infarction needs to be determined by the specific patient’s physical condition and disease, but a complete return to normal is more difficult. Massive cerebral infarction is a critical emergency and requires immediate resuscitation to save the patient’s life. It also requires comprehensive measures such as anticoagulation, improving circulation, dehydration, lowering cranial pressure, preventing cerebral edema and brain herniation, scavenging free radicals, and preventing comorbidities. For younger, more resistant patients, after timely resuscitation, comprehensive treatment, and then rehabilitation, it is possible to recover some of the functions and leave sequelae, but complete recovery is unlikely. For older patients with poorly controlled underlying disease, the mortality rate of large cerebral infarction exceeds 50%. After resuscitation and comprehensive treatment, patients’ lives can be saved, but they will be left with sequelae and require long-term observation and treatment. Patients with large cerebral infarction need rehabilitation treatment, such as hyperbaric oxygen, acupuncture, physiotherapy and functional exercise of the limbs. It is also necessary to actively treat underlying diseases, such as hypertension and diabetes, as well as to pay attention to avoid emotional excitement and excessive fatigue, and to quit smoking and alcohol.