China is a high prevalence area for hepatitis B. Every year, about 2 million newborns are infected with the hepatitis B virus due to mother-to-child transmission, and 85% of them will become chronic hepatitis B. Experts point out that how to block mother-to-child transmission of infection is a major problem facing China. At present, mother-to-child interruption is an important and effective means to prevent mother-to-child transmission. According to statistics, without any blocking measures to help mothers of hepatitis B, 95% of perinatal transmission of hepatitis B virus to infants, and after formal blocking measures to help, that is, the implementation of prenatal, postnatal active or passive joint immunization of the whole process of intervention, can be made to hepatitis B virus mother-to-child transmission of the blocking efficiency increased to more than 90%, the possibility of contagion will be reduced to 5% or so, and intrauterine infections is to lead to the main reason for the emergence of this 5%. Intrauterine infection is the main cause of this 5%. How to stop this remaining 5% transmission possibility? A more effective clinical measure is to break through the bottleneck of intrauterine infections and to explore and develop more effective antiviral drugs. Antiviral treatment must be carried out before pregnancy planning to completely eliminate the virus in the body or control it at the lowest level to reduce the risk of infection; advocate cesarean section for hepatitis B virus-positive pregnant women; strengthen the immunization of newborns according to the plan; take appropriate isolation of mothers and infants while immunizing the newborns; and suggest that it is still appropriate to artificially feed the babies, etc. These measures can effectively control the transmission of mother-to-child transmission.