Treatment of constipation in children

Constipation is very common in children and can manifest as decreased frequency of bowel movements (≤2 times/week); dry, hard stools; difficult (laborious, time-consuming) bowel movements; painful bowel movements; and a sense of incomplete bowel movements. The reported prevalence of constipation in children ranges from 0.7% to 29.6% (median 12%), of which 90% is functional constipation. The treatment strategy of functional constipation in children mainly includes basic treatment, medication, behavior therapy, surgery and follow-up. 1.Basic treatment is based on family education, diet modification and lifestyle changes. It is necessary to drink sufficient amount of water (including water and juice in food), balanced diet (encourage breastfeeding and increase the intake of dietary fiber), appropriate exercise, and reasonable toilet training (for children over 4 years old, toileting for 5-10 min after each meal every day). If basic treatment is not effective for 2 weeks, drug treatment should be started. 2. The first choice of medication is oral osmotic laxative (polyethylene glycol or lactulose) or rectal laxative for 3-6 d to relieve fecal impaction and restore regular and comfortable bowel habits as soon as possible. After laxative treatment is completed, maintenance therapy is started to prevent reaccumulation of stool. Maintenance therapy includes dietary modification, medication and behavioral therapy, and can last for 2 months. Medications for the maintenance phase can be osmotic laxatives, stimulant laxatives, stool softeners or rectal administration. Osmotic laxatives are ions or molecules that are not readily absorbed by the intestine and create an osmotic recurrence in the intestinal lumen, keeping water in the intestine; while the added water dilates the intestinal lumen, stimulating peristalsis and softening the stool. Lactulose is indicated for all ages, while polyethylene glycol 4000 domestic is indicated for children over 8 years of age with constipation. Stimulant laxatives mainly increase peristalsis of the large intestine and promote the secretion of water and electrolytes from the distal small intestine and colon to soften stools. There is no information that osmotic laxatives can induce long-term adverse effects, such as electrolyte disturbance and mucosal damage, but there are few reports on safety assessment of pediatric application of stimulant laxatives. 3. Behavioral therapy, mind-body therapy, traditional therapy and biofeedback therapy are used for specific subjects and are not recommended as routine treatment for constipation. Probiotics for functional constipation may be beneficial, but there is a lack of high-quality evidence-based evidence. Medication should be considered for dose reduction only if it is effective for 2 consecutive months and should not be discontinued abruptly. The dose reduction can be maintained for several months to observe the change of stool looseness and frequency of defecation until a good defecation habit is established. 4.Surgical treatment is applicable to intractable constipation, such as drug treatment is ineffective, long-term constipation or those who need manual laxation, can be taken to cascade colonic enema (cecum stoma) or sigmoid colectomy. The treatment of constipation is long-term and usually easy to recur, and parents may seek treatment from multiple hospitals, so follow-up is especially important. Family education and health education should be emphasized to guide a reasonable diet and lifestyle, and the application of non-pharmacological therapies should be emphasized. We should also pay attention to the warning signs and symptoms of constipation and correct the diagnosis in a timely manner.