Clinically, chronic nephritis is not staged, and chronic renal failure can be divided into five stages. Stage IV is the glomerular filtration rate in 15-30 ml/min 1.73m2, most patients in this stage can be treated by oral medications, such as oral Haikun Renhex capsule, medicinal charcoal, compound alpha-keto acid, ferrous succinate, sodium bicarbonate; intramuscular injection of erythropoietin and other drugs. There are also some patients who are in stage IV of chronic kidney disease but have poor cardiac function or obvious edema, which cannot be relieved by the application of ordinary diuretic drugs. It is recommended that such patients actively undergo renal replacement therapy, and the most commonly used replacement methods clinically are peritoneal dialysis, hemodialysis and renal transplantation, according to the patient’s condition, choose the treatment method that suits them.