General indications are: e antigen (HBeAg) positive, hepatitis B virus DNA ≥ 105 copies/ml (equivalent to 20,000 IU/ml); e antigen (HBeAg) negative, hepatitis B virus DNA ≥ 104 copies/ml (equivalent to 2,000 IU/ml); Zhao Wenxia, Department of Splenology, Gastroenterology, Hepatology and Biliary Disease, the First Affiliated Hospital of Henan Traditional Chinese Medicine College (HAN TCMC), glutamic acid aminotransferase (ALT) ≥ 2×ULN (normal value), if treated with interferon, ALT should be ≤10×ULN, and serological total bilirubin should be <2×ULN; Glutamine transaminase <2×ULN, but liver histology Knodel HAI ≥4, or inflammatory necrosis ≥G2, or fibrosis ≥S2.