While humans use drugs to suppress the growth of viruses, the virus itself has to adapt to its environment to survive. In order to adapt to the suppressive environment created by humans, it has to undergo some changes so that it can continue to reproduce in an unfavorable environment. This is how the hepatitis B virus mutates. Hepatitis B virus mutation generally includes 3 kinds, which are hepatitis B virus surface antigen mutation, e antigen mutation, and hepatitis B virus DNA polymerase mutation. Zhao Wenxia, Department of Spleen, Gastroenterology, Hepatobiliary Diseases, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, China