First of all, liver cancer here refers to primary liver cancer, which is a tumor grown from the liver itself that has undergone malignant transformation. China is a major hepatitis B country, with 300,000 to 500,000 hepatitis B-related liver cancer patients each year, accounting for about 90% of all liver cancers. This also suggests that it is very important for all hepatitis B patients, no matter they are major triplets, minor triplets or hepatitis B carriers, to go to the hospital for regular checkups, because only early detection can get the best treatment effect. Routine surveillance screening indicators mainly include serum alpha-fetoprotein (AFP) and liver ultrasonography (US). For men ≥ 40 years of age or women ≥ 50 years of age with HBV and/or HCV infection, alcoholism, comorbid diabetes, and a family history of liver cancer who are at high risk, screening is generally done at 6-month intervals. If you are a hepatitis B patient and a mass in the liver is found during routine physical examination, then you must be highly alert to the possibility of liver cancer. How to diagnose it? It must be stated here that liver cancer diagnosis can be made based on clinical manifestations without the necessity of pathological diagnosis, i.e. there is no need to perform liver puncture biopsy, which leads to a higher risk of implantation and metastasis. Therefore, once ultrasound detects liver occupancy, an enhanced CT (must include arterial, portal and delayed phases), preferably a thin CT scan, or an enhanced MRI must be done. The diagnosis of primary liver cancer is basically clear. Then, once the diagnosis of primary liver cancer is clear, how to treat it? It must be clear that there are only three methods that can achieve radical cure, namely surgical resection, radiofrequency ablation and liver transplantation. The indications of these three methods are different and of course there are crossover, this article mainly focuses on who are suitable for surgical resection? First of all, the basic principles of hepatectomy: ① Thoroughness, maximum complete removal of tumor, so that there is no residual tumor at the cutting edge; ② Safety, maximum preservation of normal liver tissue, and reduction of surgical mortality and surgical complications. Secondly, the patient has no serious diseases such as heart and lung, can tolerate the surgery, has no extrahepatic metastasis, and has good liver reserve function. Radical hepatectomy must meet the following conditions: ① single hepatocellular carcinoma with smooth surface and clear surrounding boundaries or pseudo-envelope formation; ② multiple tumors with <3 nodes and confined to a segment or a lobe of the liver. < p=""> Finally, given the characteristics of patients with hepatocellular carcinoma in China, surgical resection can also be considered for patients with combined vascular cancer thrombosis, and combined with other treatments can also prolong patients’ survival and improve their quality of life to a certain extent. This article is authorized by Dr. Binwei Duan.