1.Pain is the symptom of advanced cervical cancer. Cancer tumor extends along the parietal tissue, invades the pelvic wall and compresses the peripheral nerves, which is clinically manifested as persistent pain in sciatic nerve or one side of sacrum and iliac region. The tumor compresses or encroaches on ureter, and the narrowing and obstruction of the duct leads to hydronephrosis, which manifests as back pain or even severe pain on one side, and further develops into renal failure, resulting in uremia. The invasion of lymphatic system leads to blockage of lymphatic vessels and obstruction of reflux, resulting in swelling and pain of lower limbs and other symptoms. 2.Systemic symptoms Advanced patients have fever due to metabolism of cancerous tissues, absorption of necrotic tissues or co-infection, and the body temperature is usually around 38℃, a few of them can be over 39℃. Due to bleeding and consumption, anemia, emaciation and even cachexia appear. 3.Metastatic symptoms of cervical cancer The cancer spreads to the front and can invade the bladder. Patients may experience frequent urination, urgent urination, painful urination, falling and hematuria, which are often misdiagnosed as urinary tract infection and delay the diagnosis. In severe cases, vesico-vaginal fistula can be formed. If the cancer spreads backward, it can invade the rectum, and there are symptoms such as cramping, difficulty in defecation, urgency and blood in the stool, etc. Further development can lead to vaginal-rectal fistula. Distant metastasis may occur in the advanced stage of the disease. The more common is supraclavicular lymph node metastasis, in which nodes or masses appear. Cancer infiltration may spread to distant organs through blood vessels or lymphatic system and metastases may appear in the corresponding areas with corresponding symptoms.