The climate in spring is weird and changeable, in the seasonal change from winter to spring, the temperature is always hot and cold, because the climate is unstable, plus the spring air pressure is low, the human body in order to adapt to this climate change, its thermoregulatory center hypothalamus will actively regulate, generally speaking, normal people can adapt to such climate change, although also easy to cause colds, spring sleepiness and other mental tiredness phenomenon. Some people are troubled by symptoms such as insomnia and anxiety, and therefore, the number of patients seeking help has increased recently. The primary symptoms of many patients are insomnia, anxiety and irritability, followed by frustration and depression, resulting in a disturbed mind and nothing to do. They may even suffer from psychiatric disorders or relapse from mental illness. Because of the large changes in sunlight and temperature in spring, it is easy to affect people’s emotions, and some small things can trigger emotional instability in this season. Even for most mentally healthy people, the changeable weather in spring can make people’s mood fluctuate and easily irritable. According to information, the human pineal gland in strong sunlight, will produce a “melatonin”, hormone less, thyroxine, adrenaline concentration will rise, but the pineal secretion of hormones in rainy and bad weather is more, thyroxine, adrenaline concentration is relatively lower. Thyroxine and adrenaline have the function of promoting cell metabolism, increasing oxygen consumption and stimulating tissue growth and maturation and differentiation. Thus, a changeable climate can lead to changes in mood through its effect on the pineal gland. People who are introverted should try their best to change their personality, communicate more with others and vent their emotions appropriately. When you find yourself in a depressed mood, you should pay attention to transferring the bad mood, listen to music or participate in outdoor activities when you are depressed, go trekking, play ball, at the same time, you should eat more vegetables and fruits. If the situation is particularly serious, you must seek professional psychiatric consultation. If there are members of the family with a history of mental illness, pay more attention to the recurrence pattern of mental illness, especially pay attention to his emotional changes, such as the sudden appearance of sleep disorders, dullness, emotional flatness, few words, lazy life, self-speaking and laughing for no reason, etc. Once the abnormal situation is found, you should seek medical attention promptly.