Pharmacologic lupus is lupus that is caused by the administration of certain medications. So far, as many as 50 drugs are known to cause drug-induced lupus, such as hydrazidiazine (hydrazinebendazole), isoniazid, procainamide, salazosulfapyridine, sulfadiazine, chlorpromazine, methyldopa, penicillamine, propranolol (psilocybin), oxenolol (psilocybin), phenytoin sodium, thioredoxin, reserpine (reserpine), thiomeproline, tapazole, furantoin, allopurinol Oral contraceptives, penicillin, tetracycline, quinidine, etc. The onset is related to the daily and total dose of medication and is usually induced after several months of common drug doses. According to research, it may be caused by the drugs changing the antigens and the body producing corresponding autoantibodies. Common symptoms of drug-related lupus include fever, myalgia, arthralgia and pericarditis and pleurisy, but these symptoms are milder than those in patients with SLE. Moreover, cheek rash, oral mucosal ulcers, Raynaud’s phenomenon and severe hair loss are less common than in SLE patients, and anemia, leukopenia and thrombocytopenia are also less common. With the exception of procaine amide-induced drug lupus with central nervous system lesions; drug-induced lupus from other drugs rarely involves the central nervous system. Renal involvement is less commonly seen. In terms of laboratory tests, drug-induced lupus may have increased sedimentation, hyperglobulinemia, and positive lupus anticoagulant, which are common in patients with systemic lupus erythematosus. The rate of lupus cell positivity is also similar to that of SLE. Lupus cells are also often found in the pericardial and pleural effusions of patients with pharmacologic lupus. The rate of positive antinuclear antibodies in drug-resistant lupus is similar to that in SLE patients, but anti-double-stranded DNA antibodies and anti-Sm antibodies are almost absent in drug-resistant lupus patients, and complement levels do not decrease, which can be distinguished from SLE. Drug-resistant lupus should be diagnosed early and discontinued promptly. Usually the symptoms of lupus disappear after several days or weeks of drug withdrawal without special treatment. In patients with drug-induced lupus, clinical symptoms improve after discontinuation of certain drugs, but serological abnormalities may persist for several years. For the very few patients whose clinical symptoms do not subside after stopping the drugs, non-steroidal anti-inflammatory drugs such as aspirin, anti-inflammatory pain and ibuprofen can be used, paying attention to preventing the effects on the kidneys when applying such drugs. For those with serious conditions such as pleurisy and pericarditis, appropriate amounts of adrenocorticotropic hormone therapy can be used. In addition to certain drugs, there are often foods or cosmetics containing aromatic rings and hydrazines in daily life, as well as hydrazine components contained in certain foods, dyes and tobacco that can induce drug lupus and should be used sparingly or not at all.