Doxycycline is the current first-line drug for the treatment of acne. It is primarily an anti-bacterial treatment against Propionibacterium acnes. Nowadays, in addition to doxycycline, there is minocycline, which is also the main medication used to treat acne. However, both doxycycline and minocycline have an effect on the function of the liver. Therefore, when taking oral doxycycline for acne treatment, it is important to check the liver function regularly. The main scope of treatment with doxycycline is inflammation, or acne with more obvious infections, generally mild acne, is not recommended.