Osteoporosis is a common disease that seriously affects people’s quality of life, with the majority of elderly people, especially women. Once osteoporosis occurs, we should pay attention to exercise, strengthen nutritional regimen and develop good living habits, and also carry out the necessary medication to reduce bone loss and prevent the deterioration of symptoms. Commonly used drugs are mainly the following categories: 1, calcium: increase calcium intake, can make the negative calcium balance to positive calcium balance, conducive to bone reconstruction, and positive calcium balance bone increased, can reduce the occurrence of fractures. The daily dietary supply of calcium for the elderly should be at least 800 mg, but the intestinal absorption function of the elderly is generally poor, and dietary intake is mostly insufficient, so it is best to take additional calcium supplements, and the older you are, the more calcium supplements should be taken, and for those over 65 years old, the daily calcium supplement should be 1500-2500 mg. For women, calcium supplementation is especially important, from the stage of growth and development stop to 35 years old, calcium intake should generally be 800-1000 mg per day, and the daily calcium intake for women before and after menopause should not be less than 1000 mg, and if they do not take estrogen, the daily calcium intake should be increased to 1500 mg. To ensure sufficient calcium, it is obviously not possible to rely on dietary intake alone, and additional supplementation is needed . However, patients with kidney stones or patients with high urinary calcium and the risk of kidney stones should be cautious with calcium supplementation. 2, vitamin D and active products: calcium absorption requires vitamin D. The combined balanced use of the two can reduce the secretion of serum parathyroid hormone, so that the amount of bone calcium back into the blood is significantly reduced, increasing bone calcium. People with osteoporosis are often resistant to vitamin D, so the dosage should be increased to 4000 international units per day. At present, the more commonly used is Lorgeldo, given daily 0, 5mg is the most effective, but also the safest. 3, sex hormones: sex hormones in the body can promote the synthesis of proteins in the bones, stimulate the growth of bone cells, and maintain the strength and sturdiness of bones. Some sex hormones can be appropriately supplemented to help prevent osteoporosis. Men can supplement with long-acting testosterone preparations, which can enhance bone cell activity, inhibit bone resorption and increase bone mineral density. Women, especially postmenopausal women, should supplement some estrogen because estrogen can reduce the sensitivity of bone tissue to parathyroid gland, stimulate bone throwing bone cells to produce bone matrix, inhibit bone resorption, correct negative calcium balance, and also reduce urinary calcium and urinary hydroxyproline to achieve the effect of preventing bone calcium from being drawn back into the blood. However, the use of sex hormones should be carried out under the guidance of a doctor, and the dosage, duration of treatment and discontinuation of the drug should be determined according to the specific situation, and close attention should be paid to the reaction after use, especially whether there is liver damage and endometrial proliferation and functional bleeding. Elderly people with arteriosclerosis should be cautious with the drug. 4, calcitonin: calcitonin has the effect of inhibiting osteoclast activity, reducing the number of osteoclasts and decreasing bone conversion. In addition, calcitonin has a pain-relieving effect. However, it should be used in combination with calcium preparations to overcome the excessive lowering of blood calcium by calcitonin and aggravate bone recycling. Side effects such as nausea and vomiting may occasionally occur during use. Its effective time is short, generally in 12-16 months, and resistance will occur with prolonged use. 5, sodium fluoride: sodium fluoride can stimulate bone formation and increase the amount of cancellous bone bone. General daily dose of 50-80 mg, while calcium supplementation, can be alternated with six months of medication and six months of discontinuation. However, sodium fluoride has more side effects, the use of the dose should not be too large, and should be used under the guidance of a doctor. 6, bisphosphonates: bisphosphonates can reduce bone resorption, inhibit the activity of osteoclasts, and can increase the amount of loose bone bone throughout the body. Currently commonly used is bone phosphorus, 400 mg of oral daily, 3 months as a course of treatment. If the disease is more serious can be used first injection, intravenous drip, can be continuous infusion 3-5 days, but should not exceed 7 days, otherwise it will cause hypocalcemia. 7.Zoledophosphate: MIGUDA (zoledronic acid injection), indications for the treatment of postmenopausal women with osteoporosis. For the treatment of Paget’s disease (deformational osteitis). 8, other drugs: some drugs with the effect of nourishing the liver and kidney, connecting bones and tendons, strengthening the body and bones, such as Xianling Bone Capsules, etc. The treatment process of osteoporosis is complicated, and the electrolyte level as well as liver and kidney function should be checked regularly during the course of taking medication, and medication should be taken under the guidance of a doctor, and multiple medications should not be taken on their own to avoid side effects. In case of limb fracture, if the physical condition is good, surgical plate internal fixation should be performed as soon as possible; in case of vertebral fracture, treatment by minimally invasive surgery (PKP) should also be performed as soon as possible to avoid aggravating osteoporosis with long-term bed rest.