Acne is the most common chronic inflammatory follicular sebaceous gland disease, which occurs in adolescent males and females, and can often be naturally alleviated or cured after puberty; individual patients can be delayed until they are over 30 years old.
1, endocrine factors: androgens play a vital role, because the development and secretion of sebaceous glands are governed by androgens.
2, abnormal keratinization of follicular sebaceous gland ducts: excessive keratinization of follicular sebaceous gland ducts, small caliber of ducts, narrow obstruction, affecting the normal discharge of follicular shed epithelium and sebaceous glands, forming acne.
3, microbial infection: sebum is produced under the action of Propionibacterium acnes lipase, which produces free fatty acids and stimulates inflammation of hair follicles.
4.Immunological factors: Some patients have increased IgG levels.
5, other factors: genetic factors affect the clinical type, distribution of lesions and duration of disease; dietary factors such as fat, sugar, cocoa, etc. increase sebum secretion. Stimulating food, overexertion, mental tension, etc. can also aggravate the skin lesions.