Patients with hepatocellular carcinoma may manifest pain in the right upper abdomen and liver area, which may also radiate to the right shoulder back, mainly around the shoulder joint, especially if the tumor involves the diaphragm, the patient’s symptoms of this pain are more obvious. In some cases, bone metastasis occurs due to the development of tumor, which can also metastasize to the ribs or scapula, manifesting as pain in the scapular region and also accompanied by obvious limitation of movement of the affected upper limb. With the development and evolution of liver malignant tumor, there will be significant anemia, hypoproteinemia and complication of ascites formation, the patient will also have significant abdominal distension and irregular hypothermia, and the large amount of ascites will also restrict the movement of diaphragm. Patients may present with chest pain, distension, and, in severe cases, dyspnea. Early diagnosis of malignant tumors of the liver should be actively surgical, while patients with advanced disease can be controlled by adjuvant interventional therapy and, if necessary, pain management.