Thermal ablation is to cause coagulative necrosis of cancer tumor by inputting energy such as laser, microwave and radiofrequency to produce thermal effect in the tumor. Its prominent advantages are low invasiveness and low impact on body function, and the treatment-related mortality rate of percutaneous ablation is 0.1% to 1.0%. Some scholars even found that percutaneous thermal ablation for early-stage hepatocellular carcinoma can achieve local efficacy and 3-year survival rate similar to that of surgical resection, so it is considered to have the advantages of minimally invasive, simple, economic and reproducible. Thermal ablation therapy can be considered as one of the preferred treatments for early-stage liver cancer. However, when the tumor is located in the periphery of the gallbladder, thermal ablation has certain limitations and is even considered as a contraindication. Because the tumor is located in the periphery of the gallbladder, the operator is forced to abandon ablation of the tumor tissue close to the gallbladder to avoid damaging the adjacent gallbladder and avoiding necrotic perforation of the gallbladder, which may easily lead to incomplete ablation or local recurrence. Some scholars have reported a case of conventional percutaneous thermal ablation leading to colonic injury complicated by intestinal fistula. Although it was cured by local drainage and intravenous nutrition, the hospitalization time reached 63d, which greatly increased the degree of trauma and medical cost. For the ablation of tumors around the gallbladder, in order to reduce or avoid complications while achieving complete ablation of the tumor as much as possible, we first performed laparoscopic cholecystectomy using a minimally invasive approach and thereafter performed ablation of the liver tumor. In our study, none of the patients had complications related to thermal ablation treatment and laparoscopic surgery, and complete ablation of liver tumors was achieved in all cases. In conclusion, laparoscopic cholecystectomy followed by thermal ablation of liver cancer around the gallbladder effectively improves the effect of thermal ablation in treating liver cancer, avoids the occurrence of complications, and expands the indications for thermal ablation treatment, which is worth promoting.