The etiology of thrush is mainly oral Candida infection. In the treatment of antifungal treatment, the current treatment method recommends the application of mycotoxin, using two mycotoxin tablets grinded into powder and mixed with 20mL of glycerin for oral application treatment, 3-5 times/day, 1 time before bedtime, in the course of treatment should not be less than two weeks. Note that after the disappearance of symptoms to continue to use the drug, to prevent the course of treatment is less than, the disease repeated. In addition, it can be combined with sodium bicarbonate for treatment, dilute sodium bicarbonate into 1.4% liquid, daily oral cleaning care, to maintain a local weak alkaline environment in the mouth, which is not conducive to the growth of fungi. Secondly, special attention should be paid to the disinfection of bottles and the cleanliness of the mother’s nipples in the daily care of the pediatrician.