Mouth sores are also called recurrent aphthous ulcers. Suffering from recurrent aphthous ulcers is painful, affecting eating, speech, mood and quality of life due to painful irritation. Since there is no curative treatment available, the principles of treatment for the disease are to find the causative factors, remove possible causative factors, maximize the interval period, enhance physical fitness, reduce local symptoms, and promote ulcer healing. Pain-relieving and anti-inflammatory drugs can be applied to the ulcer to prevent secondary infection and reduce local symptoms. Preference is given to local treatment, in which topical glucocorticoids have become the first-line drug for the treatment of recurrent aphthous ulcers. For patients with more severe symptoms and frequent recurrences, a combination of local and systemic drugs is used. For ulcer attacks, 0.1% to 0.2% chlorhexidine gluconate solution, 0.5% povidone-iodine solution, 0.1% ezacridine solution, 0.2% ciprochloronium gargle or compounded boric acid solution can be used to gargle the mouth. Lysozyme tablets 20mg, cetiolium 0.5mg containing chemistry, 3 to 4 times a day. For pain relief, compound chamomile lidocaine can be applied to the ulcer locally. To promote ulcer healing, topical trimethoprim oral cream or recombinant human epidermal growth factor gel can be used. For specific medication, please refer to the clinical situation and follow the doctor’s instructions. For deep and large periglandular mouth sores that do not heal for a long time, tretinoin suspension or prednisolone acetate suspension 0.5-1 ml can be added to 2% procaine 0.3-0.5 ml and injected at the base of the ulcer once a week. In addition, you need to pay more attention to oral hygiene, brush your teeth carefully to avoid the ulcer site, use a soft-haired toothbrush to insist on comprehensive and thorough brushing; drink more boiled water, eat more fresh fruits and vegetables, eat a light and easily digestible diet, eat more fluid food, chew slowly, do not eat spicy and stimulating food, ensure smooth bowel movements, stop smoking and drinking alcohol; keep your mood relaxed and happy, avoid mood swings, pay attention to Combine work and rest, avoid overexertion, get enough sleep, do not stay up late; exercise to enhance physical fitness.