Condyloma acuminatum in men is a common sexually transmitted disease caused by human papilloma virus infection. It is usually found in the anus and genital area, the age of onset is between 18-45 years old, the main means of transmission is sexual contact. In men, the initial manifestation is mainly in the circumcision, coronal sulcus, urethra and other parts of the body, which can start as small light red papules and gradually increase in size, either singly or in clusters. The surface is moist and soft, papilliform, coronary, or cauliflower-like protrusion, easily bleeding, also easy to erosion, oozing. The base is usually tipped and the surface is usually grayish or red. The current acetic acid white test can be used to give a clear diagnosis, in clinical treatment, the main can be external medicine and laser and other physical therapy, the effect is generally good. For specific diagnosis and treatment, it is recommended to go to a clinical hospital to give a clear diagnosis and personalized treatment.