Hepatitis B and liver cancer More than 85% of liver cancer patients in China have hepatitis B virus infection. Long-term chronic hepatitis and cirrhosis not only develop into liver cancer, but also greatly reduce the reserve function of the liver, which seriously affects the treatment and prognosis of liver cancer. It is well known that hepatitis B is a trilogy: hepatitis B – cirrhosis – liver cancer. Chronic infection with hepatitis B virus will cause repeated and progressive inflammation and necrosis of liver cells, regeneration of liver cells and proliferation of fibrous tissue; mutation of “undesirable molecules” will occur in regenerated liver cells to form cancer cells. The immunity of cirrhotic patients cannot destroy these “bad molecules” in time, which gives cancer cells a chance to take advantage of the situation and eventually form cancerous tumors. If alcohol is allowed to further damage the liver, the risk of liver cancer will be 1+1>2. Alcohol abuse is definitely a cancer gas pedal. Patients with chronic hepatitis B/C and cirrhosis are at high risk of liver cancer, especially those with a family history of liver cancer, and in accordance with the requirements of China’s “Standard for the diagnosis and treatment of primary liver cancer”, men aged ≥40 or women aged ≥50 with HBV and/or HCV infection, alcoholism, combined with diabetes mellitus are at high risk of liver cancer. According to the requirements of China’s primary liver cancer diagnosis and treatment standard, men or women aged ≥40 or ≥50 years with HBV and/or HCV infection, alcoholism, combined diabetes, and family history of liver cancer should have serum fetoprotein (AFP) and liver ultrasound examination every 3-6 months. Don’t underestimate these two tests, as they are very easy and practical to detect most early liver cancers. This is a proven protocol that has been proven by numerous medical studies, including tumor cell multiplication time and numerous epidemiological surveys, and is recognized by the medical community. Special Note: Patients with chronic liver disease should pay attention and seek early medical examination if they have: 1) persistent and progressive liver pain; 2) weight loss and wasting without specific reasons.