In 2004, the IARC (International Agency for Research on Cancer) concluded that HPV (human papillomavirus) infection is necessary for the development of cervical cancer and cervical intraepithelial neoplasia; without persistent HPV infection, the likelihood of cervical cancer in women is almost zero. The 2012 U.S. cervical cancer screening guidelines have proposed: a screening protocol with both cytology and HPV. HPV typing test has been gaining increasing attention and its significance is: 1. for screening of cervical lesions; 2. to guide further management of patients with ASCUS, LSIL, HSIL; 3. to provide data for the development of HPV vaccine. Information. In a multicenter study of 3,607 cervical cancer patients from 25 countries worldwide reported by IARC, the mean infection rate of HPV 16 among all HPV-positive cervical cancer patients was 57.4% , followed by HPV 18. Thus, HPV types 16 and 18 are strongly predictive of cervical cancer risk.