1. What is gout? Gout is a group of diseases caused by disorders of purine metabolism. Its clinical features are hyperuricemia and the resulting recurrent attacks of gouty acute arthritis, gouty stone deposits, gouty stone chronic arthritis and joint deformities. It often involves the kidneys and causes chronic interstitial nephritis and uric acid kidney stone formation. According to the cause of increased uric acid in the blood can be divided into two categories: primary and secondary. The cause of primary gout is hereditary due to congenital disorders of purine metabolism. Secondary gout can be caused by kidney disease, leukemia, drugs, food and other causes. The disease is characterized by redness, swelling, heat and pain in the joints, recurrent attacks and inflexible joint movement. 2. What causes gout? There is a substance called purine in the body, and when its metabolism is disturbed, it causes gout. Purine through a series of metabolic changes, the final product formed called acid. Uric acid has no physiological function in the body. Under normal circumstances, 2/3 of the uric acid produced in the body is excreted by the kidneys and 1/3 by the large intestine. Uric acid in the body is continuously produced and excreted, so it is maintained at a certain concentration in the blood. In the process of synthesis and decomposition of purine, there are various enzymes involved, and the disorder of metabolism due to the congenital abnormality of enzymes, which increases the full formation or decreases the excretion of uric acid, can cause hyperuricemia. When the blood uric acid concentration is too high, uric acid is deposited in the form of sodium salts in joints, soft tissues, cartilage and kidneys, causing inflammatory reactions in the tissues that become the root cause of gout. If the treatment is not complete, it can lead to joint enlargement, deformation, stiffness, petechiae and nodules around the joints, complications of gouty kidney stones, gouty kidney failure, gouty coronary heart disease, hyperlipidemia, hypertension, urinary stones and other internal diseases that threaten the life of the patient until the end of life.