Rapid pain relief from urinary stone pain can be achieved with painkillers, usually starting with non-steroidal anti-inflammatory drugs, and if the pain is still not relieved, non-opioid analgesics, or even opioid analgesics, are required. Urinary stones cause pain mostly because the stone is embedded in a narrow part of the urinary tract during expulsion, causing smooth muscle spasm and resulting in an attack of renal colic. It can be treated with symptomatic pain relief, stone removal treatment or stone extraction treatment. Symptomatic analgesic treatment is based on the degree of pain and the choice of different analgesics, usually starting with non-steroidal anti-inflammatory drugs, such as the use of indomethacin suppositories for anal insertion. If the pain is still not relieved, non-opioid analgesics, or even opioid analgesics, need to be chosen. Non-opioid analgesics usually choose tramadol, opioid drugs mostly choose pethidine injection, pay attention to the use of opioid analgesics must be used when using antispasmodic drugs. Antispasmodic and analgesic drugs such as 654-2 intramuscular injection can relieve smooth muscle spasm. However, the use of pain medication only provides temporary relief of pain. To fundamentally resolve stone pain, the stone must be removed for radical treatment. Removal of stones can be considered as lithotripsy, lithotripsy, surgery or interventional stone extraction. During the treatment phase, it is necessary to drink more water so that the daily urine volume is maintained at 2000-3000 ml, together with diuretic and antispasmodic drugs. The dilution of urine facilitates the flushing and discharge of small stones and helps to prevent recurrence. In short, only when the stones are expelled from the body can the kidney stone pain be cured.