Patients with advanced hepatocellular carcinoma present with swollen feet as well as swollen lower extremities, which is a sign of significant hypoproteinemia. The survival time in this condition varies from 3-6 months, with significant variability in each individual. The most common cause of lower extremity swelling is low protein, but there is also a cause of advanced liver cancer complicated by large amount of ascites and increased pressure in the abdominal cavity which affects the venous blood return to the lower extremities, which may also lead to swelling and in severe cases, deep vein thrombosis in the lower extremities. This condition is a manifestation of advanced stage, which can be treated symptomatically, including plasma supplementation, albumin, diuretic treatment or laparotomy to reduce the pressure of abdominal cavity and drainage of fluid, which can alleviate the patient’s condition to a certain extent and achieve the purpose of prolonging survival.