Menopause syndrome is an inescapable process in the life journey of many women, the key is how to face it and treat it in time. Menopause shows a wide range of symptoms and is most likely to be accompanied by depression, bringing an unpleasant atmosphere to the family. Please pay attention to it early and treat it promptly. Please treat the following symptoms promptly. Emaciated face, sluggish gaze, poor appetite, decreased physical fitness, and decreased libido. Female patients often have menstrual disorders or amenorrhea. Insomnia is an early sign for many patients, or poor sleep in general, which is aggravated by menopause, where early awakening is most common clinically, full of pessimism slow speech, low voice, slow response, and significant resistance to overcome every word and movement. In the most severe cases, there can be a state of miosis. In patients with agitated depression, there is a significant increase in speech and movement, anxiety and fear, and agitation and self-injury, which is very dangerous. In severe depressive states, the patient may be silent and bedridden, which is called depressive rigidity. Suicide attempts and behaviors are the most dangerous symptoms in depressed patients. Initially, the depression may be characterized by a short period of time in which the patient’s ability to experience emotions is diminished, he or she is listless and uninterested in everything. The patient feels a sense of uncertainty about the future, a complete loss of joy, and a sense of misanthropy. The heavy emotional depression always brings self-blame and guilt, and the patient feels that he or she has lost the ability to work. Patients may refuse to eat or will only eat white food because of delusions of guilt. Suicide or self-punishment may occur in cases of extreme depression. In some patients with depression, physical symptoms are obvious, often manifested as recurrent or persistent headache, dizziness, chest tightness, shortness of breath, general weakness, palpitations, constipation, abnormal appetite, weight loss, etc. The depressive symptoms are often masked. The depressive symptoms are often masked. The physical examination often does not show any positive findings, and these patients are often seen in internal medicine for a long time and are often mistaken for neurosis, which is also one of the symptoms of menopausal depression.