In China, there are currently more than 100 million perimenopausal people, 30 to 40% of whom will experience more obvious menopausal symptoms, thus affecting their work and life. It is essential to take positive measures to cope with these symptoms, which are conducive to the well-being and harmony of families and society. Usually, adopting a healthy lifestyle, adjusting a calm state of mind, traditional Chinese medicine and symptomatic treatment can improve the situation of some mild cases. However, for severe menopausal patients, the use of more effective sex hormone replacement therapy (MHR) is the most effective measure that cannot be replaced. Sex hormone replacement therapy is the only perimenopausal therapeutic measure that targets the cause of the disease. Due to the negative impact of a 2002 study in Europe and the United States, some Chinese people have developed a prejudice against the harmful effects of MHR. Currently, the rate of SRT in China is less than 1% of perimenopausal patients, and in the better regions, it is less than 3%. In Europe and the United States, the utilization rate is as high as 30-40% in most countries due to the widespread awareness of new research findings. For this reason, many Chinese women suffer unnecessarily from menopausal conditions. In fact, after the debate on the safety of sex hormones in 2002, scientists have come to the conclusion that there is a safe “time window” in further research. This conclusion has been generally accepted by the International Menopause Society, the North American Menopause Society, the British Menopause Society, as well as relevant authoritative academic organizations in Asia, such as China, and a consensus has been reached at different levels. Less than 60 years old and less than 10 years after menopause, it is safe to use sex hormone replacement therapy in moderation. The above time period is the so-called “time window” of safety. Women with menopausal symptoms can use the medication with complete confidence. In reality, the percentage of healthcare workers in Xiehe Hospital who use sex hormone replacement therapy is as high as 35.7%, and the percentage of those who continue to work in the clinic until they reach the age of 70 years old is as high as 70%, which is much higher than that of those who do not use the drug, which is less than 8%. This is an important and positive message. There is no doubt that the correct use of sex hormone medication is an important and safe means of effectively combating menopausal conditions. However, a completely laissez-faire and random application will still bring some problems, and systematic and standardized management is also necessary. Necessary assessment and monitoring measures should also be taken in sex hormone replacement therapy. First, the indications need to be correctly grasped. For severe hot flashes, insomnia, irritability and other menopausal symptoms, genitourinary tract atrophy, osteoporosis active use is necessary. Other menopause-related problems need to be assessed by a medical professional and used judiciously. Secondly, individualization of medication is also very important and should not be done in a one-size-fits-all manner. Individualization is an important principle of sex hormone replacement, each patient’s own characteristics should be fully considered, such as age, years of menopause, complaints, the purpose of treatment, and whether there are cardiovascular disease and other high-risk factors, etc., respect for individual needs and desires, after I fully understand the advantages and disadvantages of sex hormone replacement therapy, combined with the characteristics of the drug, the individualization of medication. The individualization of the program, the individualization of the dosage, the individualization of the route of medication, and the individualization of the duration of treatment, in an effort to achieve the best results and the least adverse reactions. Again, systematic management, monitoring and follow-up are essential. This measure will further guarantee the safety of women who use the drug, which will greatly benefit the long-term use of the drug and achieve a good outcome in the prevention and treatment of related chronic diseases. For this reason, a basic physical examination and investigation prior to the administration of the drug should not be omitted. Next, individualization of the medication. Then, regular follow-up. Usually, follow-up visits are made once at 1, 3 and 6 months after the first administration of the medication, and annually thereafter. The frequency of follow-up visits should be increased for those with specific physical ailments. The pros and cons should be evaluated at each follow-up visit, and the medication can be continued as long as the benefits outweigh the disadvantages. At the same time, minor physical discomfort should be adjusted, and the medication regimen can be adjusted if necessary. Maximize medication safety. Menopause is one of the most important stages in a woman’s life, and it is also an eventful time when a variety of illnesses occur frequently. Effective prevention and treatment of menopausal illnesses is crucial to improving the quality of life and enjoying a good life. Women, especially middle-aged and elderly women, need a healthy body to meet the changing of the years. They need to face all the difficulties and challenges of the “second life” openly, and the only way is to use all modern means, including hormone supplementation therapy, to accumulate the energy of life, to face the difficulties of the future and to enjoy the beautiful music of life!