The clinical incidence of female menopausal syndrome is high, and patients suffer a lot. Modern medicine adopts hormone replacement therapy, which has a long medication time, big side effects, and is not easy to be accepted by patients;. In contrast, Chinese medicine treatment of menopausal syndrome can significantly improve the symptoms and has low side effects. Relative to hormone replacement (HRT) therapy has certain advantages. However, there are some problems, first of all, there is insufficient knowledge of the etiology of menopausal syndrome, most medical doctors believe that the onset of menopausal syndrome is blamed on the kidneys, and treatment is mostly started from tonifying the kidneys, and tonifying the kidneys can not control the patient’s symptoms of depression very well. Moreover, clinical treatment emphasizes medication and is light on psychological adjustment. These problems are all based on the unknown cause of menopause syndrome. Early symptoms of menopausal syndrome are characterized by mental and emotional symptoms. Moreover, women’s physiology is closely related to the liver. Modern research has also proved that there is a relationship between the liver’s main function of detoxification and the activity of estrogen receptors. Therefore, clinical treatment is based on liver detoxification, and kidney tonic is given appropriately. The patient’s emotional problems are well controlled. Secondly, Chinese medicine has made some achievements in the treatment of menopausal syndrome, but there is no clear research on the prevention of menopausal syndrome, which is due to the lack of understanding of the etiology and pathogenesis of menopausal syndrome, and it is difficult to carry out the preventive work when the root cause of the disease cannot be found. We propose that the pathogenesis of menopausal syndrome is mainly due to kidney deficiency and liver depression, which is the starting point for early intervention and elimination of susceptible factors, which will effectively prevent the occurrence of menopausal syndrome.