Ar-He knife and Iodine 125 particles are two different minimally invasive treatment techniques, each with its own characteristics, which can be used in combination to achieve complementary advantages. Ar-He knife is characterized by rapid, ultra-low temperature local ablation, which can rapidly form ice spheres of different volumes within a short period of time, resulting in necrosis of the tumor tissue and local inactivation of the tumor. However, the inactivation area formed after freezing and thawing is often more regular (similar to the shape of the ice ball), which may leave some residuals for some tumors with irregular shape. Especially when the tumor is near important structures such as blood vessels, bile ducts and intestinal ducts, sometimes the scope of cryoablation needs to be controlled in order to avoid serious postoperative complications as much as possible, and residuals are more common. Iodine 125 particles are characterized as brachytherapy and continuous local radiotherapy, which can achieve continuous treatment within the half-life. Due to the small energy of individual particles, it is less likely to cause extensive damage in the vicinity of important structures, and is more controllable and less risky. The combination of argon helium knife and iodine 125 particles can both rapidly reduce tumor load and achieve effective control of residual tumors in close proximity to vital structures, while reducing possible treatment-related risks and improving patient quality of life. Thus, it is currently recommended for the comprehensive treatment of refractory hepatocellular carcinoma, liver metastases, and breast cancer cases.