There is no therapeutic effect of applying toothpaste to acne on the face because acne may be caused by a local conditional pathogenic infection on the face, such as Propionibacterium acnes infection, or Staphylococcus albicans infection, and produce inflammatory changes. Toothpaste is a cleanser that not only cannot have an anti-inflammatory effect, but also tends to irritate the skin causing acne to worsen when applied to the acne area, therefore, applying toothpaste to acne on the face is not recommended. Acne on the face, also known as acne, can be treated by applying local ointments. For inflammatory papules and pustules, you can apply topical fusidic acid cream, clindamycin gel, peroxymethylphenidate gel and other drugs, combined with oral minocycline hydrochloride capsules to kill disease-causing microorganisms. In case of acne-like rashes, such as whiteheads or blackheads, topical topical application of adapalene gel or retinoic acid cream can be applied to promote normal epidermal metabolism and inhibit keratin formation, thus achieving therapeutic effects. In addition, during the treatment period, you need to avoid sweet, greasy and spicy stimulating food, including raw onion, raw garlic, strong tea, coffee, chili, mustard, cream, etc., and to keep the bowels open, to ensure a good mood and sleep, can promote the recovery of acne.