Recently, we performed pancreaticoduodenectomy for a liver transplant patient with hepatocellular carcinoma. The patient was one year post liver transplantation for liver cancer and had been taking doxorubicin for treatment. He developed obstructive jaundice, CT found occupancy of the head of the pancreas, endoscopic biopsy suggested adenocarcinoma, and stent placement failed, so he decided to have pancreaticoduodenal surgery, which was very difficult, but the procedure went well, but the postoperative pathology reported metastatic liver cancer. The patient is now recovering well after surgery, the obstructive jaundice disappeared, and he continues to take Doxylamine treatment. Although the decision to perform pancreaticoduodenectomy in this case was made due to an incorrect preoperative pathological diagnosis, in turn, it reminds us that in this type of patients, if there is a possibility to remove metastatic lesions, the patient’s survival can also be prolonged by removing the metastatic lesions. This patient is still under postoperative follow-up and no other signs of recurrence or metastatic lesions have been detected. In the recent period, we have performed several consecutive pancreaticoduodenal resections for patients with lower bile duct tumors that were considered by outside hospitals as impossible to perform pancreaticoduodenal resection, and all of them were successful.