Many people know that high blood uric acid will attack gout, often see some patients because the physical examination found high uric acid, in order to avoid the onset of gout rushed to take uric acid-lowering drugs, resulting in the onset of arthritis, what is it? Gout arthritis is an inflammatory reaction caused by the local formation of crystals of sodium uric acid in the joints. The solubility of uric acid in serum is 7mg/dl, the higher the level of uric acid, the greater the risk of gout attack. Acute attacks of gout are mainly due to rapid fluctuations in blood uric acid concentration. With a sudden rise in blood uric acid, uric acid forms crystals that precipitate in the synovial fluid to form needle-shaped urates; with a sudden drop in blood uric acid, the surface of already formed gout stones dissolve and release insoluble needle-shaped crystals. The urate microcrystals can chemotactic white blood cells, and the white blood cells engulf the crystals and release inflammatory factors (such as IL-1, etc.) and hydrolytic enzymes, leading to cell necrosis and the release of more inflammatory factors, which may cause joint cartilage dissolution and soft tissue damage, which is an acute attack (redness, swelling, and heat). Gout attacks are not always high blood uric acid, some are induced by local formation of uric acid crystals in acute arthritis, while blood uric acid is not high. To avoid rapid fluctuations in blood uric acid, uric acid-lowering drugs often need to be increased gradually from very small doses. The specific choice of uric acid-lowering drugs requires a uric acid-lowering regimen based on the individual patient, not a one-size-fits-all medication, for example, to promote uric acid excretion or to inhibit uric acid production. Therefore, when elevated blood uric acid is found, it is important to consult a rheumatologist with expertise to develop an individualized and reasonable uric acid-lowering program, and reasonable treatment can prevent recurrent gout attacks. In hospitals without a rheumatology department, you can also consult with an endocrinologist.