According to Chinese medicine, radiation has the characteristic of “heat and poison”, which acts on human body through skin and hair, leading to excessive heat and poison and damaging qi, blood and fluid. Modern medical research shows that when radiotherapy is applied to oropharyngeal tumors, the oral cavity will be irradiated, the glands will be damaged, the mucous membrane will be congested and edematous, and the mucous membrane will be dysfunctional, which will cause mucous membrane ulcers, affecting the eating, and in serious cases, forcing the radiotherapy to be stopped, which will reduce the efficacy of the treatment. According to this pathophysiology, we apply heat-cleansing and detoxification as the rule of treatment in the clinic to treat radiological oropharyngeal reactions. Heat-removing and detoxifying drugs can protect the mucous membrane of the oropharynx and reduce the radioactive damage. In the radiotherapy of oropharyngeal tumors, we applied Angong Niuhuang Wan to prevent and treat radiological oropharyngeal reactions, and achieved good therapeutic effect. Angong Niuhuang Pill is the most prestigious traditional medicine in China. The prescription comes from Wu Jutong’s “Articles on Warm Diseases” in the Qing Dynasty, and it is one of the effective medicines for treating heat toxicity in Chinese medicine. In the past ten years, Beijing Tongrentang has applied modern high-tech means to carry out pharmacological research on Angong Niuhuang Pills, and the results have proved that Angong Niuhuang Pills have clear antipyretic, anti-inflammatory and sedative effects. It is effective in clearing heat and removing toxins, expelling phlegm and opening up orifices. It is mainly used for treating the heat symptoms of warm diseases. Composition of Angong Niuhuang Pills: oxalis, rhinoceros horn, tulip gold, scutellaria, yellow rhizome, gardenia, andrographis, vermilion sand, ice tablet, musk, pearl, gold foil for coating. Formulas and medicines: oxalis is cool in nature, can clear heat and detoxification, but also can tranquilize the spirit and calm the alarm; Rhinoceros horn clear heat and cool blood, diarrhea and detoxification, can enter the camp blood to solve the heat and poison in the blood; Musk opens the orifices and wakes up the brain, passes through the meridian, three medicines are used together, clearing heat and detoxification effect are very fast and strong, for the king’s medicines; Scutellaria baicalensis, yellow rhizome, Gardenia jasminoides, bitter cold and clearing the heat, Huang Huang Lian clearing heat of the middle jiao, Gardenia diarrhea, while the heart opens the orifices of the tongue, scutellaria baicalensis is specializing in clearing fire of the upper jiao, the three products are the formula for the ministerial medicine ; Supplemented with cinnabar, pearl sedative through the heart orifices, ice tablet aromatic to help musk, andrographis antidote toxins and eliminate filth, all drugs together to achieve the function of clearing heat and removing toxins.