1. Patient factors: earlier age of onset, longer duration of illness, slow onset, unprovoked onset, combined with serious physical illness, character defects, social insufficiency before onset, drug dependence, intolerance to drugs, non-compliance with treatment, lack of awareness of one’s own mental illness, early onset of negative symptoms. 2.Disease factors: Different mental illnesses have different treatment effects. For example, mental retardation, autism and Alzheimer’s disease have poor treatment effects. About 1/3 of patients with schizophrenia are treated poorly, and affective disorders are treated better. 3. Family history of mental illness: Second and third generation family members of parents with mental illness. 4.Medical factors: wrong diagnosis, improper treatment, inadequate treatment, and inconvenient access to medical care for patients. 5, family and social support system: high emotional expression of family members or indifference to patients, discrimination, poor social support. 6, doctor-patient relationship: poor doctor-patient relationship, lack of trust is difficult to achieve good results.