Uric acid is the end product of purine metabolism. The saturation and concentration of uric acid in the body is about 420μmol/L (7mg/dl) at 37℃, exceeding this concentration is called hyperuricemia. When uric acid exceeds the saturation concentration, urate crystals precipitate out and can be directly deposited in joints and surrounding soft tissues, kidney tubules and blood vessels, etc. Long-term hyperuricemia can cause a series of serious consequences. 1, gout: gout asymptomatic period, the patient may not have any discomfort, only the blood uric acid persistently or fluctuating elevation, this period can last for several years or decades. The acute attack of gout is mainly manifested by sudden onset of single joint redness, swelling and heat pain, mostly at night or in the morning during sleep, the lower extremity foot joints are common, the first metatarsal toe joint is the most common, can also spread to the knee, fingers, wrist, elbow and other joints. At this time, the patient often feels that the joint swelling and pain is severe and unbearable, like a knife cut or insect bite. However, most of them are self-limiting, even without the use of drugs, the joint symptoms can be relieved within a few days or 2 weeks, or even disappear. 2. Gout stones: If the condition is not well controlled, acute gout can be frequently attacked, and enlarged gout stones can gradually appear, distributed in the auricle, foot, hand, elbow and other places, affecting the appearance. Gout stones present around the joints can erode the bone surface of the joints and cause chronic joint inflammation, resulting in persistent joint swelling, pain, and even joint deformity. 3. Kidney: ① Gouty nephropathy: uric acid salt deposited in the kidney can cause gouty nephropathy, resulting in symptoms such as hematuria, proteinuria, edema, anemia, hypertension, and renal colic. (ii) Uric acid nephrolithiasis: It can vary from no obvious symptoms to manifestations such as renal colic, hematuria, difficulty in urination, hydronephrosis, pyelonephritis or perinephritis. ③Acute renal failure: A large number of urate crystals block the renal tubules, renal pelvis and even ureter, and the patient suddenly develops oliguria or even anuria, which can develop into acute renal failure. 4. Eye: Recurrent episodes of conjunctivitis, keratitis and sclerenitis can occur. The fundus optic disc is often mildly congested, and the retina can become exudate, edema or exudative retinal detachment. Therefore, long-term hyperuricemia can cause a series of serious consequences, so patients must pay attention to the active treatment to minimize the development of adverse consequences.