Proteinuria is caused by primary glomerular disease, the pathogenesis of which is no more than the two ends of deficiency and reality. Spleen deficiency is the main cause of spleen spleen deficiency, which is the loss of spleen qi to consolidate the essence leaking out or deficiency of middle qi, which leads to the lowering of qi, while kidney deficiency is the main cause of kidney qi deficiency and inability to consolidate, and evil reality is mostly due to dampness and blood stasis. The diabetic nephropathy, often in the lower stage of thirst, more Yin deficiency and fire to the development of Qi and Yin deficiency and finally long-term disease and kidney, Yin loss and Yang, so the treatment at this time to benefit the Qi and fix the kidney, according to the different severity of the mutual loss of Yin and Yang, add nourishing the kidney Yin and benefit the kidney Yang products. However, the false note is that this disease is after all based on yin deficiency, dry heat as the standard, support Yang need to stop in the disease, not too much. Proteinuria in hypertensive kidneys is characterized by the internal movement of liver wind that disturbs the kidneys, resulting in the leakage of essence from the urine, as this disease is relatively mild, solid treatment should be based on nourishing the liver and kidneys, converging the phase fire and resting the liver wind. For proteinuria caused by autoimmune diseases, the pathogenesis of wind-dampness disturbing the kidney is more prominent. On the basis of regular strengthening of the spleen and kidney, we need to pay attention to the treatment of dispelling wind-dampness, such as adding Xu Changqing, Qingfengtang, and Pierced Mountain Dragon. In addition, lupus, dry syndrome and other diseases, mostly Yin deficiency and blood heat are more common, so the medicine should be calm and clear, not too much dry heat to provoke the outbreak of the disease.