There is a consensus that hepatitis B carriers do not need treatment, but is it the same for an infected person who has been carrying the hepatitis B virus for a long time, especially if he is older than 40 years old, waiting for a chance to be treated? This question is exactly what I am currently thinking about. Here we look at the pathology of infected patients with normal liver function, which deserves further thought by our hepatologists. Some literature shows that liver tissue biopsy of infected patients with normal liver function results in more than 90% of infected patients with varying degrees of liver inflammation and fibrotic changes. I believe that if our control the age of infected patients with liver tissue biopsy above 40 years, the positive rate results will be higher. Hepatitis B is the most common cause of primary liver cancer. There is no fundamental treatment for liver cancer, and prevention of liver cancer is the most fundamental measure. Liver cancer occurs on top of cirrhosis to varying degrees, so preventing the occurrence of cirrhosis and stopping the progression of cirrhosis to the greatest extent possible is the goal of our treatment. Liver tissue biopsy helps us to understand the inflammation and fibrosis of the liver in advance or more clearly, to keep track of the disease in time, and to effectively control the progression of liver disease is the result that our doctors and patients pursue together.