Depending on the type of disease inherited, the chance of inheriting a disease across generations ranges from 5% to 50%. Heredity, which often serves as a common factor in the acquisition of diseases, includes monogenic and polygenic inheritance, where monogenic inheritance includes recessive and dominant inheritance. In addition to this, there is a more complex type of inheritance, which is not only related to genes but also to the environment, that is, multiple pairs of genes as well as the environment work together to determine the genetic characteristics of the offspring. 1. Recessive inheritance: the probability of intergenerational inheritance of recessive diseases is 0-50%, which mainly depends on the incidence of recessive diseases and the problem of carrying them. If inherited from autosomes, the probability of inheritance of such diseases has nothing to do with male and female genders, but if it is located in sex chromosomes, the probability is quite different between different genders. 2. Dominant heredity: dominant heredity has a greater relationship with the number of genes carried by the patient, and the probability of intergenerational inheritance is mostly around 50%, but the marriage of different genes may make a difference. 3. Polygenic diseases: the inheritance of such diseases is not only determined by a pair of genes, but also by the consequences caused by the joint decision of multiple genes, the probability of intergenerational inheritance of this genetic disease has not yet had an accurate value. 4. Genetic inheritance and environmental co-determination: the occurrence and development of some diseases are not only affected by genes, but also affected by environmental factors in the growth and development of later life. For this kind of diseases, if the genetic inheritance is not satisfied with the results, it can be appropriate to create favorable conditions in the environment of later life to make up for the congenital deficiencies. Some genetic diseases are fatal, so if there is a family genetic predisposition, you should go to the hospital as soon as possible for screening and diagnosis.