Restless legs syndrome is a relatively common condition that usually manifests clinically as extreme discomfort in both lower extremities during sleep at night, forcing the patient to keep moving the lower extremities or walking down to the floor, resulting in severe sleep disturbances. Although the disease is not life-threatening, it seriously affects the quality of life of patients. Epidemiological data from abroad indicate that its prevalence is 1 to 10% of the total population, and the prevalence in China is estimated to be around 1.2 to 5%, common in middle-aged and elderly people. The syndrome is divided into two categories: primary and symptomatic. 1, primary restless legs syndrome The cause of this type is unknown, and a few patients have a family history. 2, symptomatic restless legs syndrome RLS is also secondary to other diseases and is commonly due to the following causes: uremia, iron deficiency anemia, folic acid deficiency, pregnancy, rheumatoid arthritis, Parkinson’s disease, multifocal neuropathy, metabolic diseases and medications. Diagnostic criteria: The International Restless Legs Syndrome Study Group has developed a minimum diagnostic criteria consisting of four symptoms 1. Abnormal sensations: Indescribable discomfort in the limbs leading to a strong desire to move the limbs, mainly the lower limbs. These abnormal sensations often occur in the deep parts of the limbs. 2. Motor symptoms: The patient cannot sleep and keeps moving the limbs to relieve the abnormal sensations. The main manifestations are walking back and forth, constantly shaking or flexing and extending the lower limbs, or grinding and turning in bed. 3. Symptoms are aggravated at rest and can be temporarily relieved by activity. 4. The symptoms are aggravated at night and reach a peak late at night. Treatment: Patients with RLS should pay attention to sleep hygiene and regular work and rest. Use less coffee and coffee-containing beverages, quit smoking, and drink less alcohol or hot baths before bedtime. Excessive daytime sleepiness should be avoided to reduce the resulting sleep disturbances. Medication Dopaminergic medications are preferred. If the patient has contraindications to dopaminergic medications, such as cardiac arrhythmias or psychiatric disorders, or has developed serious side effects, a switch to opioids may be considered. Clonidine may be used alternatively or in combination with dopaminergic drugs or opioids. Anticonvulsants such as carbamazepine and gabapentin are used as second-line drugs and can be used when the above drugs are ineffective or the side effects are not tolerated.