Diagnosis of malignant glioma 1. The clinical manifestations of malignant glioma are not specific, and the symptoms of neurological deficits with increased intracranial pressure are predominant. 2. MRI plain scan with enhancement is strongly recommended as the main imaging diagnosis, supplemented by CT. 3. MRI special functional examination, PET and SPET are recommended for differential diagnosis, preoperative assessment and efficacy evaluation. Surgical treatment of malignant glioma 1. Maximum safe resection of tumor is strongly recommended. That is, the maximum extent of surgical resection of tumor lesions with the maximum preservation of neurological function. 2.It is recommended that for those who cannot perform maximum range safe resection of tumor, partial resection of tumor, open biopsy or stereotactic (or under navigation) puncture biopsy can be used as appropriate, and the histopathological diagnosis of tumor has been clarified. Principles of radiation therapy for malignant glioma 1. It is recommended to start radiotherapy as soon as possible about 2-4 weeks after surgery. 2.Conventional segmentation (1.8-2.0Gy/time, 5 times/week) of 6-10MVX-ray external irradiation is highly recommended. 3.The recommended standard dose is 60Gy/30-33 times. 4. SRS (x-knife, gamma knife) is not recommended as the preferred treatment modality for malignant glioma after surgery. Newly diagnosed glioblastoma 1.Temozolomide synchronous radiotherapy combined with adjuvant chemotherapy regimen is highly recommended. 2. ACNU, VM-26 are recommended for those who are not eligible for temozolomide Newly diagnosed mesenchymal glioma Radiotherapy combined with temozolomide or application of nitrosoureas chemotherapeutic agents are recommended.