There is no particularly good treatment for Melkersson-Rosenthal syndrome. Treatment can be divided into two aspects: (1) Clofazimine, which may have some efficacy, usage 100 mg twice daily orally for 10 days, then twice weekly orally for 4 months. (2) Vitamin D. (3) Anti-tuberculosis drugs. (4) Quinoline drugs. (5) Corticosteroids. The latter four treatments may be effective in the early stage, but are not effective in the late stage. 2.Surgical treatment: Plastic surgery can be considered for giant lip if it affects the appearance.