Patient: Patient, 75 years old. She had breast cancer five years ago and underwent resection and chemotherapy, but at the end of September, she had fever, bone pain, blood alcohol 75, bone scan and bone metastasis (generalized), and her body is weak. Shen Zhan, Department of Medical Oncology, Shanghai Sixth People’s Hospital: Elderly breast cancer patients with higher risk of chemotherapy can choose endocrine therapy, provided that: the patient’s cancer cells are estrogen and progesterone receptor positive, or at least one of them is positive; together with the treatment of bisphosphonates, such as Zeta. If the patient has fractures in the spine and spinal cord compression symptoms, local treatment must be given as soon as possible.