Bone cement plasty has immediate pain relief and fracture stabilization effects, which can significantly improve the quality of life of oncology patients. However, its use in clinical practice is still short, and many scholars believe that this technique lacks long-term follow-up data and more case validation, and the treatment of metastases at complex sites still deserves in-depth analysis. Objective: To retrospectively analyze the effect of radiation therapy alone and cementoplasty supplemented with radiation in the treatment of patients with bone metastases from malignant tumors. 2006-09/2009-02 Sixty patients with bone metastases from malignant tumors admitted to the Sixth People’s Hospital of Shanghai were randomly divided into two groups: 30 patients in the simple radiotherapy group, using 6 MV X-rays with an irradiation dose of 2 Gy/time, 5 times/week for 4 weeks, and a total irradiation dose of 40 Gy; 30 patients in the combined group, using cementoplasty treatment and supplemented with radiotherapy. Bone pain was scored using a combination of the VRS method of pain grading and visual analogy scoring, and the onset of effect was measured. RESULTS AND CONCLUSIONS: The bone pain scores of the two groups were basically similar before treatment (P > 0.05); after treatment, the combined group showed significant pain relief and a significant decrease in bone pain scores compared with the radiation-only group (P < 0.05). A total of 13 patients in the radiation-only group and 8 patients in the combination group were ineffective, and the onset of effect was later in the radiation-only group than in the combination group. During the 10-month follow-up period, a total of 25 patients died in the radiation-only group and 21 patients died in the combination group, with more patients surviving in the combination group than in the radiation-only group during the different follow-up periods. No evidence related to bone cement was found in any of the deaths, suggesting that the use of bone cement forming with radiation for the treatment of bone metastases is more effective than radiation therapy alone for pain relief and can be the treatment of choice for bone metastases.