Bone metastases are the main cause of cancer pain, and the pathological damage it causes seriously affects the survival and quality of life of patients. Many patients with advanced bone metastases from tumors experience severe bone pain, resulting in a sharp decline in quality of life, loss of belief in survival, and also causing pain to their families at the same time. Cancer pain treatment is divided into two parts: ① treating the cause of the disease and eliminating the pathophysiological mechanism that produces pain; ② simple analgesic treatment, which achieves pain relief by altering the central nervous system’s perception of injurious stimuli and blocking the nerve conduction pathway. With the development of modern medicine, the diagnosis and treatment of pain in bone metastases have also made great progress, and the treatment mainly includes the following aspects: ① Drug therapy is the most basic treatment method. At present, the drugs commonly used in the treatment of bone metastasis pain are analgesics with bone resorption inhibitors, and the drugs that can inhibit the activity of osteoclasts, such as bisphosphonates, play an important role in the treatment of bone metastases. The third generation of bisphosphonates – zoledronic acid (zoiedronic acid) can effectively reduce and delay the occurrence of bone complications caused by bone metastases from a variety of solid tumors, as well as effectively prevent and treat associated bone loss. It can also prevent bone metastasis, maintain bone mineral salt density and treat malignant hypercalcemia. It is regarded as the current gold standard for the treatment of bone metastases; ② Radionuclide treatment for bone metastatic tumors is a kind of treatment method with remarkable effect, small side effects and direct killing effect on tumors, which occupies an important position in the treatment of bone metastatic tumors, and it is applicable to clinically confirmed bone metastatic tumors that cannot be relieved from the pain by chemotherapy and radiotherapy; ③ Chemotherapy and endocrine therapy are effective for special tumors, such as small-cell lung cancer, Thyroid cancer, prostate cancer, malignant lymphoma and leukemia, etc., which have certain effects on reducing pain, shrinking tumor volume and slowing down the development of bone metastases; ④ Radiation therapy can significantly relieve pain, and there are data suggesting that radiation therapy can make the pain relieving rate up to more than 80% and control the development of the disease, with less side effects and long-lasting efficacy; ⑤ In recent years, domestic and foreign treatments are used for the foci with osteolytic destruction of bone metastasis tumors with ⑤ In recent years, domestic and foreign countries use polymethyl methacrylate (PMMA) bone cement to fill in the foci of osteolytic destruction of bone metastases, which has gained ideal pain-relieving effect, and this method has been made a routine means of treating vertebral body destruction in foreign countries; ⑥ Traditional Chinese medicine, anaesthesia and surgery can also solve the problem of bone pain, and the indications should be strictly selected. The psychological adjustment of patients with bone metastatic tumor is also very important. The occurrence, development and regression of malignant tumors are related to psychosocial, which is called the category of psychophysiological disorders, so psychological treatment is essential and vital, and should try to do a good job in cooperating with patients’ families and colleagues. Most of the advanced cancer patients have received surgery, radiotherapy, chemotherapy and other treatments, they have a heavy psychological burden, pain aggravates the pain, most patients will show disappointment, nervousness, fear, depression and even despair, and at this time, the family should give the patient to create the opportunity to talk about the venting of emotions, the desire to survive can be increased in some patients after the venting of emotions. At the same time, professional individualized psychological care should be carried out. Psychological care goals should be clear, targeted, to solve patient-specific or individualized psychological problems. Commonly used psychological intervention methods include cognitive intervention, relaxation training, hypnosis and suggestion, distraction and supportive therapy, and role model learning method. The psychological care awareness of nursing staff should be strengthened, learning should be enhanced, and advanced methods should be adopted. Try to reduce and eliminate the patient’s psychological and physical burden, and strive for the best therapeutic effect. In case the condition allows, it is still recommended that family members consult a bone tumor specialist, who will offer valuable advice, so that patients with terminal cancer can live with quality and dignity, and will not be in pain every day, and will not be paralyzed in bed, resulting in the inability to take care of themselves and the loss of courage and dignity of life, and also bring a great burden to the family.