It is not necessarily a mental illness to be unable to stop laughing all the time. Some people may simply be in a more exuberant mood recently. However, if the symptom of not being able to hold back laughter persistently appears in more serious, solemn and other inappropriate occasions, it is suspected that it may be related to mild mania, psychosis and other disease factors, and it is recommended to go to the hospital to improve the relevant examination and treatment: 1. Mild mania: endocrine disorders, neurological disorders and other reasons may lead to the occurrence of mild mania, mainly manifested as always being unable to hold back laughter, feeling energetic, daily Various symptoms of high emotion such as increased amount of daily speech. Uncontrolled mild mania will gradually develop into psychosis, so it is recommended that people with the above-mentioned conditions go to the hospital for relevant examinations in a timely manner; 2, psychosis: psychosis is also clinically known as mental disorder, and people with the disease will not only be unable to stop laughing, but also accompanied by hallucinations, delusions, cognitive decline, affective disorders and other symptoms of mental disorders. In serious cases, there is even a tendency to self-harm or aggressive behavior; 3, other: always can not help laughing may also be a strong laugh performance, although these people are clear consciousness, logical thinking ability is normal, but also often appear to be unable to restrain the laughter, common in Parkinson’s, traumatic brain injury, brain tumors, cerebral arteriosclerosis and other organic brain lesions of people. In addition, people with hyperthyroidism and other hormone secretion may also have the symptom of always being unable to stop laughing. If it is caused by psychiatric diseases, the clinical first choice is anti-psychotic drugs, supplemented by psychological counseling for treatment. If it is caused by some organic disease, it is recommended to actively deal with the primary disease in order to relieve the symptoms.