The prostate is a gland that surrounds the man’s bladder and is the size of a kernel around the urethra, and is unique to men. According to statistics, there are 70,000 to 80,000 new cases of prostate cancer in China every year, and 95% of them occur in older people over 60 years of age, and the incidence of prostate cancer continues to increase with age. The incidence of prostate cancer continues to increase with age. Clinically, prostate cancer mostly occurs in the outer gland, and there are no symptoms in the early stage, and even if there is discomfort, it is not enough to attract patients’ attention. When the tumor enlarges and compresses the urethra, it is often confused with an enlarged prostate. Therefore, about 80% of patients find distant metastatic lesions first, and then prostate cancer is found. At this time, the lesion is already in advanced stage and the prognosis is poor. Early stage prostate cancer is one of the few cancers that can be cured by surgical intervention and can not affect the patient’s life expectancy at all. It is clear that early detection of prostate cancer is very important. The clinical symptoms of prostate cancer and their severity depend on the speed of growth of the cancer and the degree of compression of the urethra. Since the prostate gland surrounds the urethra, the cancer first presses on the urethra and shows the symptoms of abnormal urination. At the beginning, frequent urination and increased nighttime urination can be seen; when the mass increases and presses the urethra, thin urine flow, poor urination and prolonged urination will occur; a few patients may experience painful urination and some may have hematuria, which should be alarmed at this time. When the cancer gradually increases, the compression of the urethra will be more serious, making it difficult to urinate and causing urine retention in the bladder, causing the bladder to fill up and swell to a high degree, which is extremely uncomfortable. In addition, when prostate cancer metastases, especially pelvic metastases, pain in the lower back or symptoms similar to sciatica can occur, and the pain can often radiate to the perineum and around the anus. Therefore, any man over the age of 45 who experiences frequent urination, increased nocturia, prolonged urination, thin urine stream and difficulty in urination should consider the possibility of having prostate cancer. It is recommended that men over 45 years of age should have an annual rectal examination, which is extremely important for early diagnosis. The accuracy rate of rectal examination is 50% to 70%, which can lead to early diagnosis and radical treatment. It has been reported that in the US military system, where regular rectal examinations are performed, 50% of prostate cancer cases are found to be curable, while only 5% of the cases found in the general population are curable. This shows the importance of early rectal examination. In addition, the clinical application of the prostate specific antigen (PSA) test has provided great convenience in improving the accuracy of prostate cancer diagnosis. annual physical examinations for men over 60 years of age should be performed to detect PSA in most cases at the early stage of prostate cancer development so that timely treatment measures can be taken. In addition to rectal examination, for suspicious patients, trans-perineal and rectal puncture should be performed to take biopsies, which is the only gold standard to confirm the diagnosis of prostate cancer at present. Especially, the B-ultrasound guided transrectal prostate puncture biopsy developed in recent years has not only greatly improved the accuracy of biopsy, but also helped a lot in clinical staging. Therefore, for patients with PSA > 4ng/ml, timely prostate puncture biopsy is recommended for early detection of prostate cancer.