In general, it is recommended to use adapalene gel at night and wash it off in the morning after waking up. Adapalene gel is a topical medication of the retinoic acid class, which has the effect of dissolving acne and correcting abnormal epidermal keratinization and differentiation, thus inhibiting the occurrence of common acne. Adapalene has a certain degree of photosensitivity, so it is recommended to cleanse the face at night before going to bed, wait for the skin to dry and then apply a small amount of Adapalene gel to the skin where the drug is to be applied, rub it gently away and be careful not to apply it too thickly. Adapalene gel after topical application, there may be erythema, burning sensation and other irritating reactions, related to the effect of the drug, when reducing the number of times or stop using the drug, the above-mentioned adverse reactions will gradually disappear, can also be gradually tolerated, patients do not have to worry too much.