There are three forms of condyloma acuminatum infection, warts visible to the naked eye, subclinical infection with normal appearance, or latent infection. The former can be determined by the naked eye, while the latter two can be detected by the white acetate test and molecular biology methods, respectively. Warts are caused by human papillomavirus (HPV) infection and are often found on the external genitalia and anus. They appear as single or multiple small reddish papules with soft texture and sharp tips, which gradually increase in size and become papilla-like or cauliflower-like and easily break down. Typical clinical manifestations can be determined by the naked eye. The HPV infection has a latent period. For some local skin with normal appearance, which is not recognizable to the naked eye, the white acetate test can also be positive, i.e. subclinical infection; there are also some vinegar white tests which are negative but the presence of HPV can be detected by molecular biology, such as PCR, which is called latent infection. This is because condyloma acuminata is a viral infection and is closely related to the patient’s own resistance. When the resistance is strong, the virus may turn negative on its own, i.e. not all HPV infections will eventually develop into condyloma acuminata. At present, clinically, warts visible to the naked eye are the hallmark of treatment, and subclinical infections and latent infections are not specifically addressed. Patients suspected of having warts should carefully observe the mucosal junction, and if new warts are found promptly improve the relevant tests, all of which can clearly diagnose the disease in its early stages.